Apraclonidine (hydrochloride)

A α2-AR agonist

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库存: 现货

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促销价

数量
5mg

￥762.00

610.00

- +
10mg

￥1262.00

1010.00

- +
25mg

￥2287.00

1830.00

- +

已选 0 种 0 瓶

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货号: ajci69902
CAS: 73218-79-8
别名: 盐酸安普乐定,ALO 2145
分子式: C9H10Cl2N4?HCl
分子量: 281.6
纯度: >98%
溶解度: DMSO: Slightly Soluble,Methanol: Slightly Soluble
储存: Store at -20°C
库存: 现货

Background

Apraclonidine is an α2-adrenergic receptor (α2-AR) agonist and structural analog of clonidine . It binds to α2-ARs in calf cortex, rat kidney, and rat spleen with IC50 values of 0.9, 4.3, and 4.2 nM, respectively. Apraclonidine also binds to α2-ARs in rat cerebral cortex, pig submandibular gland and lung tissue, and in dog kidney membrane (Kds = 0.87, 5.28, 1.30, and 5.25 nM, respectively). It inhibits noradrenaline-stimulated contraction in guinea pig ileum and rabbit vas deferens (EC50s = 7.59 and 6.76 nM, respectively). Opthalmic formulations containing apraclonidine have been used to treat elevated intraocular pressure.