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  • Becatecarin
Becatecarin的可视化放大

Becatecarin

A water-soluble antineoplastic antibiotic

原价
¥3625-10062
价格
2900-8050
Becatecarin的二维码

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  • 库存: 现货
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  • 货号: ajci70066
  • CAS: 119673-08-4
  • 别名: NSC 655649; BMS 181176; BMY 27557
  • 分子式: C33H34Cl2N4O7
  • 分子量: 669.6
  • 纯度: >98%
  • 溶解度: DMSO: Soluble,Water: Soluble
  • 储存: Store at -20°C
  • 库存: 现货

Background

Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin. It intercalates into DNA, stabilizing the DNA-topoisomerase complex. This results in the potent catalytic inhibition of both topoisomerases I and II, initiating DNA cleavage and apoptosis. Becatecarin, alone or in combination with other compounds, has anti-cancer as well as myelosuppressive effects in vivo. It is also a transport substrate of the ATP-binding cassette (ABC) transporter ABCG2.

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