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安捷凯生物医药，安捷凯化学
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  2. Bacterial
  3. Bischloroanthrabenzoxocinone
  • Bischloroanthrabenzoxocinone
Bischloroanthrabenzoxocinone的可视化放大

Bischloroanthrabenzoxocinone

An inhibitor of FAS-II

原价
￥5712-19862
价格
￥ 4570-15890
Bischloroanthrabenzoxocinone的二维码

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  • 库存: 现货
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  • 货号: ajci70128
  • CAS: 866022-28-8
  • 别名: BABX, (―)-Bischloroanthrabenzoxocinone
  • 分子式: C28H24Cl2O7
  • 分子量: 543.4
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

Bacterial type II fatty acid synthesis (FAS-II) is mediated by a series of enzymes, each of which may be targeted by potential antibiotics. Bischloroanthrabenzoxocinone (BABX) is an inhibitor of FAS-II, blocking fatty acid synthesis in S. aureus and E. coli with IC50 values of 11.4 and 35.3 µg/ml, respectively. It inhibits the growth of S. aureus and permeable E. coli strains with minimum inhibitory concentrations ranging from 0.2-0.4 µg/ml. BABX also displays binding to liver X receptors (LXRs), inhibiting agonist binding in an LXRα-scintillation proximity assay (IC50 = 10 µM).

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