BMP-22
An inhibitor of autotaxin
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包装价格促销价数量
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1mg￥1837.001470.00- +
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5mg￥7762.006210.00- +
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10mg￥13575.0010860.00- +
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25mg￥31687.0025350.00- +
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- 货号: ajci70144
- CAS: 1306684-90-1
- 别名:
- 分子式: C22H39O3P
- 分子量: 382.5
- 纯度: ＞98%
- 溶解度: DMF: 20 mg/ml,Ethanol: 10 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
BMP-22 is an inhibitor of autotaxin (IC50 = 170 nM). It is selective for autotaxin over the phosphodiesterases NPP6 and NPP7 at 10 μM. BMP-22 (0.1-1,000 nM) inhibits autotaxin-mediated production of lysophosphatidic acid (LPA) from lysophosphatidylcholine in vitro in a concentration-dependent manner. It inhibits LPC-dependent MM1 cell invasion of a human umbilical vein endothelial cell (HUVEC) monolayer. BMP-22 (0.5 mg/kg per day) decreases the number of lung metastatic foci in a B16/F10 syngeneic mouse melanoma model of lung metastasis.
