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- PTEN (Phosphatase and tensin homologue deleted on chromosome 10)
- bpV(phen) (potassium hydrate)
bpV(phen) (potassium hydrate)
An inhibitor of phosphatases
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包装价格促销价数量
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5mg￥800.00640.00- +
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25mg￥2400.001920.00- +
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- 货号: ajci70180
- CAS: 171202-16-7
- 别名: Bisperoxovanadium(phen), Potassium Bisperoxo(1,10phenanthroline) oxovanadate (V)
- 分子式: C12H8N2O5V?K+(H2O)3
- 分子量: 404.3
- 纯度: ＞98%
- 溶解度: DMSO: 1 mg/ml,PBS (pH 7.2): 10 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
bpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 38 nM). It also inhibits the vascular endothelial PTP, PTP-β (IC50 = 343 nM), and PTP-1β (IC50 = 920 nM). At 0.1 mM, bpV(phen) inhibits SH2 domain-containing inositol 5'-phosphatase-2. Presumably by inhibiting insulin receptor kinase-associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase.
