安捷凯生物医药
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  • CAY10561
CAY10561的可视化放大

CAY10561

A selective inhibitor of ERK

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

CAY10561的二维码
  • 库存: 现货
可选规格
  • 包装
    价格
    促销价
    数量
  • 500ug
    ￥412.00
    330.00
    - +
  • 1mg
    ￥787.00
    630.00
    - +
  • 5mg
    ￥3312.00
    2650.00
    - +
  • 10mg
    ￥5737.00
    4590.00
    - +
已选 0 种 0 瓶
金额: ￥0.00
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使用我司产品发表的文章

  • 货号: ajci70576
  • CAS: 933786-58-4
  • 别名: Pyrazolylpyrrole ERK Inhibitor
  • 分子式: C22H17Cl2FN4O2
  • 分子量: 459.3
  • 纯度: >98%
  • 溶解度: DMF: 2.5 mg/ml,DMSO: 1.5 mg/ml,Ethanol: 5 mg/ml,Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 µM) and JNK3 (Ki = 4 µM). CAY10561 inhibits proliferation of COLO 205 cells with an IC50 value of 0.54 µM.

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