现货大促销，价格低至8折起，量大更优惠，详细咨询客服
安捷凯生物医药，安捷凯化学
全部分类
全部分类
  1. 首页
  2. ERK
  3. CAY10561
  • CAY10561
CAY10561的可视化放大

CAY10561

A selective inhibitor of ERK

原价
￥412-5737
价格
￥ 330-4590
CAY10561的二维码

所有产品仅用于科学研究，我们不为任何个人用途提供产品和服务

询价有惊喜，量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajci70576
  • CAS: 933786-58-4
  • 别名: Pyrazolylpyrrole ERK Inhibitor
  • 分子式: C22H17Cl2FN4O2
  • 分子量: 459.3
  • 纯度: >98%
  • 溶解度: DMF: 2.5 mg/ml,DMSO: 1.5 mg/ml,Ethanol: 5 mg/ml,Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 µM) and JNK3 (Ki = 4 µM). CAY10561 inhibits proliferation of COLO 205 cells with an IC50 value of 0.54 µM.

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服