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安捷凯生物医药，安捷凯化学
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  2. HDAC (Histone deacetylases)
  3. CAY10722
  • CAY10722
CAY10722的可视化放大

CAY10722

A SIRT3 inhibitor

原价
￥512-9000
价格
￥ 410-7200
CAY10722的二维码

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  • 库存: 现货
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  • 货号: ajci70644
  • CAS: 388086-13-3
  • 别名:
  • 分子式: C21H14Cl2N2O2
  • 分子量: 397.3
  • 纯度: >98%
  • 溶解度: DMF: 10 mg/ml,DMSO: 10 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml,Ethanol: slightly soluble
  • 储存: Store at -20°C
  • 库存: 现货

Background

CAY10722 is an inhibitor of sirtuin 3 (SIRT3), a class III HDAC (71% inhibition at 200 µM). SIRT3 is involved in modulating metabolic homeostasis as a NAD+-dependent protein deacetylase in the mitochondria. SIRT3 functions as either an oncogene or tumor suppressor, depending on cancer cell type. High SIRT3 expression in patient-derived esophageal cancer tissues is associated with shorter survival and, in mice, downregulation leads to a lower tumor load. In contrast, low SIRT3 expression in patient-derived breast cancer cells is correlated with shorter survival.

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