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  • Caylin-1
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Caylin-1

A novel nutlin-3 analog with cell growth-promoting properties

原价
¥1037-8212
价格
830-6570
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  • 货号: ajci70656
  • CAS: 1207480-88-3
  • 别名:
  • 分子式: C30H28Cl4N4O4
  • 分子量: 650.4
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

Nutlin-3 is an activator of p53 that functions by inhibiting the interaction of p53 with MDM2, a negative regulator of p53 activity. Caylin-1 is a nutlin-3 analog which contains chlorine substituents at the 3 and 4 positions on two of the phenyl rings rather than a single 4-chloro as seen in nutlin-3. At high concentrations, caylin-1 inhibits the growth of HCT116 cells with an IC50 value of approximately 7 µM, making it about 7-fold less potent than nutlin-3 in the same assay. Interestingly, at concentrations at or below 1 µM, caylin-1 promotes the growth of HCT116 cells approximately 20% compared to untreated cells. The mechanism of the growth promoting properties of caylin-1 have not yet been elucidated.

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