Cephalothin sodium

A cephalosporin antibiotic

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100mg

￥550.00

440.00

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200mg

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0.00

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500mg

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货号: ajci70684
CAS: 58-71-9
别名: 头孢噻吩钠; Cefalotin sodium
分子式: C16H15N2NaO6S2
分子量: 418.42
纯度: >98%
溶解度: Water: 50 mg/mL (119.50 mM); DMSO: 50 mg/mL (119.50 mM)
储存: Store at 2-8°C
库存: 现货

Background

Cefalothin is a β-lactam cephalosporin antibiotic.^1,2 It inhibits the growth of various Gram-positive and Gram-negative bacteria, including several strains of S. pyogenes, S. aureus, C. tetani, N. gonorrhoeae, Salmonella, and Shigella (MICs = 0.1-0.2, 0.312-0.625, 0.078, 1.25, 1.56-6.25, and 3.12-12.5 μg/ml, respectively).¹ Cefalothin binds to E. coli penicillin-binding proteins (PBPs; IC₅₀s = <0.25, 16, 37, and 1 μg/ml for PBP1a, 1bs, 2, and 3, respectively, in a radioligand binding assay), which interferes with bacterial morphogenesis.² It exhibits antibacterial activity in mouse models of infection with S. pyogenes, D. pneumoniae, and S. aureus.¹ Formulations containing cefalothin were previously used in the prophylaxis and treatment of bacterial infections.

1.Boniece, W.S., Wick, W.E., Holmes, D.H., et al.In vitro and in vivo laboratory evaluation of cephalothin, a new broad spectrum antibioticJ. Bacteriol.841292-1296(1962) 2.Curtis, N.A.C., Orr, D., Ross, G.W., et al.Affinities of penicillins and cephalosporins for the penicillin-binding proteins of Escherichia coli K-12 and their antibacterial activityAntimicrob. Agents Chemother.16(5)533-539(1979)