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安捷凯生物医药，安捷凯化学
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  2. Bacterial
  3. Concanamycin B
  • Concanamycin B
Concanamycin B的可视化放大

Concanamycin B

A potent and selective inhibitor of V-ATPases

原价
￥7162-19862
价格
￥ 5730-15890
Concanamycin B的二维码

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  • 库存: 现货
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  • 货号: ajci70856
  • CAS: 81552-33-2
  • 别名: 刀豆素B
  • 分子式: C45H73NO14
  • 分子量: 852.1
  • 纯度: >98%
  • 溶解度: DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
  • 储存: Store at -20°C
  • 库存: 现货

Background

Concanamycin B is a macrolide antibiotic that selectively inhibits vacuolar type H+-ATPases, also known as V-ATPases (IC50 = 5 nM). In this way, it blocks the acidification of vacuolar organelles as well as early to late endosomal transport. Concanamycin B interferes with bone resorption and maturation of CD8 T lymphocytes. It also prevents processing of major histocompatibility complex (MHC) class II precursors in human B cells, inhibiting the expression of MHC class II molecules on the cell surface.

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