D-Glucosamine-2-sulfate (sodium salt)
D-Glucosamine-2-sulfate（钠盐）是一种内源性代谢物。
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包装价格促销价数量
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1g￥525.00420.00- +
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5g￥2400.001920.00- +
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10g￥4475.003580.00- +
- 货号: ajci71106
- CAS: 38899-05-7
- 别名: 氨基葡萄糖硫酸钠盐
- 分子式: C6H12NO8S?Na
- 分子量: 281.2
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
D-Glucosamine-2-sulfate (GlcN-2S), a sulfate derivative of glucosamine, is derived from chitin and has anti-inflammatory effects. In vitro, it reduces expression of inflammatory markers, including IL-1β, COX-2, IL-6, and TNF-α in IL-1β-activated human chondrosarcoma SW1353 cells at a minimum effective concentration of 1 μM. At the same concentration, it limits expression of matrix metalloproteinase-3 (MMP-3) and a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5), both markers of matrix degradation. Treating human primary chondrocytes with GlcN-2S stimulates proteoglycan production at a dose of 10 μg/mL and adhesion to fibronectin at a concentration of 50 μM.
