Dimethylallyl pyrophosphate and isopentyl pyrophosphate undergo condensation to yield geranyl pyrophosphate, which undergoes condensation with a second molecule of isopentyl pyrophosphate to yield farnesyl pyrophosphate.
货号：ajci71246
CAS：1186-30-7
分子式：C5H12O7P2?3(NH4)
分子量：297.2
纯度：＞95%
存储：Store at -20°C
库存：现货
Background:
Dimethylallyl pyrophosphate and isopentyl pyrophosphate undergo condensation to yield geranyl pyrophosphate, which undergoes condensation with a second molecule of isopentyl pyrophosphate to yield farnesyl pyrophosphate.[1] [2] Farnesylation is essential for the function of a number of proteins involved in signal transduction.[3][4]
Reference:
[1]. Barnard, G.F., and Popják, G. Human liver prenyltransferase and its characterization. Biochimica et Biophysica Acta 661, 87-99 (1981).
[2]. Laskovics, F.M., and Poulter, C.D. Prenyltransferase: Determination of the binding mechanism and individual kinetic constants for farnesylpyrophosphate synthetase by rapid quench and isotope partitioning experiments. Biochemistry 20, 1893-1901 (1981).
[3]. Hohl, R.J., Lewis, K.A., Cermak, D.M., et al. Stereochemistry-dependent inhibition of Ras farnesylation by farnesylphosphonic acids. Lipids 33, 39-46 (1998).
[4]. Rando, R.R. Chemical biology of protein isoprenylation/methylation. Biochimica et Biophysica Acta 1300, 5-16 (1996).
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