DMAPP (ammonium salt)
Dimethylallyl pyrophosphate and isopentyl pyrophosphate undergo condensation to yield geranyl pyrophosphate, which undergoes condensation with a second molecule of isopentyl pyrophosphate to yield farnesyl pyrophosphate.
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包装价格促销价数量
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500ug￥1188.00950.00- +
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1mg￥2250.001800.00- +
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5mg￥9125.007300.00- +
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10mg￥16000.0012800.00- +
- 货号: ajci71246
- CAS: 1186-30-7
- 别名: Dimethylallyl Pyrophosphate;二甲基烯丙基二磷酸三铵盐
- 分子式: C5H12O7P2 ? 3(NH4)
- 分子量: 297.2
- 纯度: ＞98%
- 溶解度: Methanol: 10mM NH4OH (7:3): 2 mg/ml ；Water: 25 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
Dimethylallyl pyrophosphate and isopentyl pyrophosphate undergo condensation to yield geranyl pyrophosphate, which undergoes condensation with a second molecule of isopentyl pyrophosphate to yield farnesyl pyrophosphate.[1] [2] Farnesylation is essential for the function of a number of proteins involved in signal transduction.[3][4]
Reference:
[1]. Barnard, G.F., and Popják, G. Human liver prenyltransferase and its characterization. Biochimica et Biophysica Acta 661, 87-99 (1981).
[2]. Laskovics, F.M., and Poulter, C.D. Prenyltransferase: Determination of the binding mechanism and individual kinetic constants for farnesylpyrophosphate synthetase by rapid quench and isotope partitioning experiments. Biochemistry 20, 1893-1901 (1981).
[3]. Hohl, R.J., Lewis, K.A., Cermak, D.M., et al. Stereochemistry-dependent inhibition of Ras farnesylation by farnesylphosphonic acids. Lipids 33, 39-46 (1998).
[4]. Rando, R.R. Chemical biology of protein isoprenylation/methylation. Biochimica et Biophysica Acta 1300, 5-16 (1996).
