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  2. RIP kinase
  3. Eletriptan
  • Eletriptan
Eletriptan的可视化放大

Eletriptan

An agonist of 5-HT1B and 5-HT1D receptors

原价
￥1337-19825
价格
￥ 1070-15860
Eletriptan的二维码

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  • 库存: 现货
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  • 货号: ajci71430
  • CAS: 143322-58-1
  • 别名: 依来曲普坦,UK-116044
  • 分子式: C22H26N2O2S
  • 分子量: 382.5
  • 纯度: >98%
  • 溶解度: DMF: 10 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 10 mg/ml,Ethanol: 0.1 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Eletriptan is an agonist of the serotonin (5-HT) receptor types 5-HT1B and 5-HT1D. It inhibits forskolin-induced cAMP accumulation in and induces vasoconstriction of isolated rabbit common carotid artery rings (pD2s = 7.6 and 4.9, respectively), an effect that can be blocked by the 5-HT1B antagonist SB216641 but not the 5-HT1D antagonist BRL15572. Eletriptan preferentially induces constriction of isolated human cerebral over coronary arteries (EC50s = 15.8 and 1,995 nM, respectively). Formulations containing eletriptan have been used in the treatment of migraine headache.

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