Enniatin A1

An ionophore antibiotic

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库存: 现货

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1mg

￥2800.00

2240.00

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5mg

￥11787.00

9430.00

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货号: ajci71462
CAS: 4530-21-6
别名: 恩镰孢菌素 A1
分子式: C35H61N3O9
分子量: 667.9
纯度: >98%
溶解度: DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble
储存: Store at -20°C
库存: 现货

Background

Enniatins are cyclohexadepsipeptides commonly isolated from fungi that are known to have antibiotic properties and to induce apoptosis in several cancer lines. Many function as ionophores, forming pores in cellular membranes to allow selective ion transport. Enniatin A1 is one of four major analogs in the enniatin complex . Its ionophoric activity has been described. Additionally, enniatin A1 has been found to induce apoptosis in cancer cells (EC50 = 5 µM in H4IIE rat hepatoma cells), decreasing the activation of the cell proliferation kinase, ERK (p44/p42) and inhibiting TNF-α-induced NF-κB activation.