ERK Inhibitor

An ERK inhibitor

原价

￥512-1962

价格

￥ 410-1570

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库存: 现货

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产品引用

货号: ajci71490
CAS: 1049738-54-6
别名: Extracellular Regulated Kinase Inhibitor
分子式: C14H16N2O3S?HCl
分子量: 328.8
纯度: >98%
溶解度: DMSO: 2 mg/ml
储存: Store at -20°C
库存: 现货

Background

ERK inhibitor is a cell-permeable inhibitor that binds ERK2 near its docking domain (KD = 5 µM). This prevents its interaction with protein substrates without inhibiting catalytic activity. ERK inhibitor blocks ERK-specific phosphorylation of ribosomal S6 kinase-1 and ternary complex factor Elk-1 but does not affect ERK1/2 phosphorylation by MEK1/2. Presumably through its effects on ERK, ERK inhibitor completely prevents proliferation of HeLa cells (IC50 = 15-20 µM), A549 lung carcinoma cells (IC50 = 25 µM), Sum-159 estrogen receptor-negative breast cancer cells and HT1080 fibrosarcoma cells.

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ERK Inhibitor

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Background