现货大促销,价格低至8折起,量大更优惠,详细咨询客服
全部分类
全部分类
  • Fenoldopam (mesylate)
Fenoldopam (mesylate)的可视化放大

Fenoldopam (mesylate)

An agonist of dopamine D1A and D1B receptors

原价
¥650-3450
价格
520-2760
Fenoldopam (mesylate)的二维码

所有产品仅用于科学研究,我们不为任何个人用途提供产品和服务

询价有惊喜,量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajci71562
  • CAS: 67227-57-0
  • 别名: 非诺多泮甲磺酸盐; Fenoldopam methanesulfonate; SKF-82526 mesylate
  • 分子式: C16H16ClNO3?CH3SO3H
  • 分子量: 401.9
  • 纯度: >98%
  • 溶解度: DMF: 2 mg/mL,DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL,DMSO: 1 mg/ml,Ethanol: 0.25mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Fenoldopam(SKF 82526) mesylate is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist.Target: D1 ReceptorFenoldopam is a selective dopamine-1 (DA1) agonist with natriuretic/diuretic properties. Fenoldopam stimulated cAMP accumulation in LLC-PK1 cells in a dose-dependent manner, an effect which could be blocked by the DA1-selective antagonist Sch 23390. Although fenoldopam was more potent than DA (EC50 55.5 +/- 7.75 nM vs. 1.65 +/- 0.64 microM) in stimulating cAMP accumulation in LLC-PK1 cells, the maximum stimulation obtained by fenoldopam was only 37% of the maximum stimulation obtained by DA(Emax 13.0 +/- 2.95 pmol/mg of protein vs. 35.6 +/- 10.19 pmol/mg of protein) [1]. Fenoldopam is a selective dopamine1 (DA1) receptor agonist. Most of the DA1 receptor agonist activity of fenoldopam resides in the R-enantiomer, which also shows weaker alpha 2-adrenoceptor antagonist activity Fenoldopam produces vasodilation in vascular beds that are rich in vascular DA1 receptors [2].


参考文献:
[1]. Grenader, A. and D.P. Healy, Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells. J Pharmacol Exp Ther, 1991. 258(1): p. 193-8.
[2]. Nichols, A.J., R.R. Ruffolo, Jr., and D.P. Brooks, The pharmacology of fenoldopam. Am J Hypertens, 1990. 3(6 Pt 2): p. 116S-119S.

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服