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  • Ganglioside GM1 Asialo Mixture
Ganglioside GM1 Asialo Mixture的可视化放大

Ganglioside GM1 Asialo Mixture

A sphingolipid

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¥4200-8012
价格
3360-6410
Ganglioside GM1 Asialo Mixture的二维码

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  • 货号: ajci71702
  • CAS: 71012-19-6
  • 别名: 神经节苷脂
  • 分子式: C62H114N2O23 (for Sphingosine C18:1)
  • 分子量: 1255.6
  • 纯度: >98%
  • 溶解度: Chloroform:Methanol (2:1): Soluble
  • 储存: Store at -20°C
  • 库存: 现货

Background

Ganglioside GM1 asialo is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside GM1 by neuraminidase. Ganglioside GM1 asialo is a glycolipid receptor for P. aeruginosa flagellin and stimulates defensive responses in host cells, including extracellular ATP release, calcium mobilization, and ERK1/2 phosphorylation when stimulated by flagellin and an anti-ganglioside GM1 asialo antibody. The percentage of ganglioside GM1 asialo-positive natural killer (NK) and CD8+ T cells in lung is increased in a mouse model of respiratory syncytial virus (RSV) infection compared with healthy animals. Depletion of ganglioside GM1 asialo-positive NK and T cells reduces IFN-γ levels in the lung, reduces weight loss, and increases lung viral load in RSV-infected mice. Ganglioside GM1 asialo mixture contains ganglioside GM1 asialo molecular species with C18:1 and C20:1 sphingoid backbones.

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