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  • IDFP
IDFP的可视化放大

IDFP

An MAGL and FAAH inhibitor

原价
¥937-12812
价格
750-10250
IDFP的二维码

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  • 库存: 现货
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  • 货号: ajci72024
  • CAS: 615250-02-7
  • 别名: Isopropyl Dodecylfluorophosphonate
  • 分子式: C15H32FO2P
  • 分子量: 294.4
  • 纯度: >98%
  • 溶解度: DMF: 10 mg/ml,DMSO: 12 mg/ml,Ethanol: 10 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

The endocannabinoids, 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA), are biologically active lipids that regulate diverse neurological and metabolic functions by activating the cannabinoid receptors, central cannabinoid (CB1) and peripheral cannabinoid (CB2). Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH) hydrolyze 2-AG and AEA, respectively, thus terminating their biological function. IDFP is an organophosphorus compound that dually inhibits MAGL and FAAH with IC50 values of 0.8 and 3 nM, respectively. At 10 mg/kg, IDFP elevates brain levels of 2-AG and AEA more than 10-fold, and decreases levels of arachidonic acid by a similar magnitude.

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