A dual inhibitor of CB1 and FAAH
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Isopropyl dodec-11-enylfluorophosphonate is an organophosphorus ester that antagonizes the central cannabinoid (CB1) receptor and inhibits FAAH with similar potencies (IC50s = 2 nM). At 30 mg/kg, this compound inhibits 99% of the brain neuropathy target esterase-lysophospholipase, which is attributed to causing delayed toxicity in mice.
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