LLP-3

Induces apoptosis by blocking Survivin/Ran interactions

原价

￥1437-2312

价格

￥ 1150-1850

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库存: 现货

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产品引用

货号: ajci72402
CAS: 1453835-43-2
别名:
分子式: C32H23ClN2O4
分子量: 535
纯度: >98%
溶解度: DMF: 2 mg/ml,DMF:PBS(pH7.2) (1:2): 0.3 mg/ml,DMSO: 2 mg/ml
储存: Store at -20°C
库存: 现货

Background

Survivin (also known as baculoviral IAP repeat-containing protein 5 (BIRC5)) is a member of the inhibitor of apoptosis (IAP) family that interacts with and inhibits the apoptotic function of several proteins. LLP-3 is a cell-permeable ligand of Survivin that blocks its interaction with Ran, resulting in the induction of apoptosis (IAP) in glioma stem cells (IC50 = 31 µM). It abolishes the growth of glioblastoma multiforme cell in spheres and in tumor slice cultures.

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信号通路

生命科学

有机化学

无机化学

材料科学

LLP-3

LLP-3详情

Background