Metipranolol (hydrochloride)

A β-AR antagonist

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库存: 现货

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5mg

￥1850.00

1480.00

- +
10mg

￥2950.00

2360.00

- +
25mg

￥5862.00

4690.00

- +
50mg

￥10387.00

8310.00

- +
100mg

￥18150.00

14520.00

- +

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货号: ajci72612
CAS: 36592-77-5
别名: Trimepranol
分子式: C17H27NO4?HCl
分子量: 345.9
纯度: >98%
溶解度: DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 5 mg/ml
储存: Store at -20°C
库存: 现货

Background

Metipranolol is a non-selective β-adrenergic receptor (β-AR) antagonist. It binds to primary rabbit iris and ciliary body homogenates (Ki = 34 nM) and inhibits relaxation induced by isoproterenol in guinea pig atrium and by fenoterol in rat uterus (pA2s = 8.3 and 8.4, respectively). In vitro, metipranolol (100 μM) inhibits anoxia-induced cell death in primary rat retinal cells and sodium nitroprusside-induced lipid peroxidation in rat primary retinal homogenates. In vivo, topical ocular application of metipranolol (0.3%) decreases α-chymotrypsin-induced increases in intraocular pressure (IOP) in rabbits. It also inhibits the blinking response to ocular tactile stimulation in rabbits when administered topically to the eye at a dose of 0.6%. Formulations containing metipranolol have been used in the treatment of elevated IOP in patients with ocular hypertension or glaucoma.