A macrocyclic peptide antibiotic
Micrococcin P1 is a macrocyclic peptide antibiotic that functions as an acceptor-site-specific inhibitor of ribosomal protein synthesis, effectively preventing the growth of Gram-positive bacteria without affecting that of Gram-negative bacteria.[1][2]
Reference:
[1]. Carnio, M.C., H?tzel, A., Rudolf, M., et al. The macrocyclic peptide antibiotic micrococcin P(1) is secreted by the food-borne bacterium Staphylococcus equorum WS 2733 and inhibits Listeria monocytogenes on soft cheese. Applied and Environmental Microbiology 66(6), 2378-2384 (2000).
[2]. Mikolajka, A., Liu, H., Chen, Y., et al. Differential effects of thiopeptide and orthosomycin antibiotics on translational GTPases. Chemistry & Biology 18(5), 589-600 (2011)
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