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MitoPBN的可视化放大

MitoPBN

A mitochondria-targeted antioxidant

原价
￥7087-7087
价格
￥ 5670-5670
MitoPBN的二维码

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  • 库存: 现货
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  • 货号: ajci72646
  • CAS: 652968-37-1
  • 别名:
  • 分子式: C33H37NO2P?Br
  • 分子量: 590.5
  • 纯度: >98%
  • 溶解度: DMF: 25 mg/ml,DMF:PBS(pH7.2) (1:2): 0.33 mg/ml,DMSO: 1 mg/ml,Ethanol: 0.33 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

MitoPBN is a mitochondria-targeted antioxidant. It accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect that is blocked by addition of the mitochondrial membrane potential uncoupler FCCP . MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 when used at a concentration of 250 nM in vitro but does not react with superoxide. It traps hydroxyl (IC50 = ~77 µM) and carbon-centered radicals and inhibits the initiation of lipid peroxidation in isolated bovine heart mitochondria.

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