A mitochondria-targeted redox cycler
MitoPQ is comprised of a triphenylphosphonium lipophilic cation conjugated to the redox cycler paraquat.[1] Driven by membrane potential, it accumulates selectively in the mitochondrial matrix where it produces superoxide by redox cycling at the flavin site of complex I.[1] Thus, MitoPQ selectively increases superoxide production within mitochondria and can be used as a tool either in cells or in vivo to investigate the role of mitochondrial superoxide in pathology and redox signaling.[1]
Reference:
[1]. Robb, E.L., Gawel, J.M., Aksentijevic, D., et al. Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat. Free Radical Biology & Medicine 89, 883-894 (2015).
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