Mitoquinol

A mitochondria-targeted antioxidant

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1mg

￥512.00

410.00

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5mg

￥1950.00

1560.00

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10mg

￥2587.00

2070.00

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25mg

￥5125.00

4100.00

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货号: ajci72652
CAS: 845959-55-9
别名:
分子式: C37H46O4P?CH3O3S
分子量: 680.8
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 0.3 mg/ml
储存: Store at -20°C; protect from light
库存: 现货

Background

Mitoquinol is a ubiquinone derivative that specifically accumulates in mitochondria due to the covalent attachment of the cation triphenylphosphonium. It functions as an antioxidant, preventing lipid peroxidation-induced apoptosis and protecting mitochondria from oxidative damage.

Mitoquinol是一种泛醌衍生物，由于阳离子三苯基膦的共价连接而在线粒体中特异性积累。它具有抗氧化作用，可以防止脂质过氧化引起的细胞凋亡，并保护线粒体免受氧化损伤。

Reference：
[1]. Kelso, G.F., Porteous, C.M., Coulter, C.V., et al. Selective targeting of a redox-active ubiquinone to mitochondria within cells. Antioxidant and antiapoptotic properties. J. Biol. Chem. 276(7), 4588-4596 (2001).
[2]. O'Malley, Y., Fink, B.D., Ross, N.C., et al. Reactive oxygen and targeted antioxidant administration in endothelial cell mitochondria. J. Biol. Chem. 281(52), 39766-39775 (2006).