A mitochondria-targeted antioxidant
Mitoquinol is a ubiquinone derivative that specifically accumulates in mitochondria due to the covalent attachment of the cation triphenylphosphonium. It functions as an antioxidant, preventing lipid peroxidation-induced apoptosis and protecting mitochondria from oxidative damage.
Mitoquinol是一种泛醌衍生物，由于阳离子三苯基膦的共价连接而在线粒体中特异性积累。它具有抗氧化作用，可以防止脂质过氧化引起的细胞凋亡，并保护线粒体免受氧化损伤。
Reference：
[1]. Kelso, G.F., Porteous, C.M., Coulter, C.V., et al. Selective targeting of a redox-active ubiquinone to mitochondria within cells. Antioxidant and antiapoptotic properties. J. Biol. Chem. 276(7), 4588-4596 (2001).
[2]. O'Malley, Y., Fink, B.D., Ross, N.C., et al. Reactive oxygen and targeted antioxidant administration in endothelial cell mitochondria. J. Biol. Chem. 281(52), 39766-39775 (2006).
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