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  • ML115
ML115的可视化放大

ML115

A cell-permeable STAT3 activator

原价
¥800-6000
价格
640-4800
ML115的二维码

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  • 货号: ajci72668
  • CAS: 912798-42-6
  • 别名: CID 6619100, SID 14735210
  • 分子式: C15H15ClN2O4
  • 分子量: 322.7
  • 纯度: >98%
  • 溶解度: DMF: 25 mg/ml,DMSO: 16 mg/ml,Ethanol: 0.1 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer. ML115 is an isoxazole carboxamide that acts as a cell-permeable STAT3 activator (EC50 = 2 nM) and is more than 28,000-fold selective for STAT3 over STAT1 and NF-κB. It shows no cytotoxicity against HT-1080 or NIH-3T3 cells. ML115 increases the expression of BCL3, a known STAT3-dependent oncogene, and enhances STAT3 activation by the pro-inflammatory cytokine IL-6. As the maintenance of pluripotency in mouse embryonic stem cells requires continued activation of STAT3, ML115 may be useful in maintaining embryonic stem cells in an undifferentiated state.

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