ML115

A cell-permeable STAT3 activator

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
500ug

￥800.00

640.00

- +
1mg

￥1525.00

1220.00

- +
5mg

￥6000.00

4800.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

货号: ajci72668
CAS: 912798-42-6
别名: CID 6619100, SID 14735210
分子式: C15H15ClN2O4
分子量: 322.7
纯度: >98%
溶解度: DMF: 25 mg/ml,DMSO: 16 mg/ml,Ethanol: 0.1 mg/ml
储存: Store at -20°C
库存: 现货

Background

Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer. ML115 is an isoxazole carboxamide that acts as a cell-permeable STAT3 activator (EC50 = 2 nM) and is more than 28,000-fold selective for STAT3 over STAT1 and NF-κB. It shows no cytotoxicity against HT-1080 or NIH-3T3 cells. ML115 increases the expression of BCL3, a known STAT3-dependent oncogene, and enhances STAT3 activation by the pro-inflammatory cytokine IL-6. As the maintenance of pluripotency in mouse embryonic stem cells requires continued activation of STAT3, ML115 may be useful in maintaining embryonic stem cells in an undifferentiated state.