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  2. Cannabinoid Receptor
  3. ML-184
  • ML-184
ML-184的可视化放大

ML-184

A synthetic agonist of GPR55

原价
￥612-4637
价格
￥ 490-3710
ML-184的二维码

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  • 库存: 现货
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  • 货号: ajci72676
  • CAS: 794572-10-4
  • 别名: CID2440433
  • 分子式: C25H34N4O3S
  • 分子量: 470.6
  • 纯度: >98%
  • 溶解度: DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml,DMSO: 20 mg/ml,Ethanol: 1 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

GPR55 is a G protein-coupled receptor that is weakly activated by some cannabinoids (CBs) at nM concentrations but displays a 5- to 10-fold greater stimulation in response to 1 µM lysophosphatidylinositol (LPI). ML-184 is a potent synthetic agonist of GPR55 (EC50 = 0.26 µM). It does not act at the related kynurenic acid receptor GPR35 and is a weak antagonist of CB1 and CB2 (IC50s = 21.8 and 15.1 µM, respectively). Like LPI, ML-184 induces phosphorylation of ERK1/2 and translocation of PKCβII to the plasma membrane by activating GPR55.

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