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  • Neoaureothin
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Neoaureothin

A bacterial metabolite

原价
¥5712-19862
价格
4570-15890
Neoaureothin的二维码

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  • 货号: ajci72968
  • CAS: 59795-94-7
  • 别名: NSC 260179, Spectinabilin
  • 分子式: C28H31NO6
  • 分子量: 477.6
  • 纯度: >98%
  • 溶解度: DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
  • 储存: Store at -20°C,protect from light
  • 库存: 现货

Background

Neoaureothin is a bacterial metabolite that has been found in Streptomyces. It is an androgen receptor (AR) antagonist that inhibits binding of dihydrotestosterone (DHT) to ARs (IC50 = 13 μM) and inhibits DHT-induced expression of prostate-specific antigen in LNCaP cells (IC50 = 1.75 nM). Neoaureothin is cytotoxic to A549, HCT116, and HepG2 cells (IC50s = 34.3, 47, and 37.2 μg/ml, respectively). It also has nematocidal activity against the pine wood nematode B. xylophilus (LC50 = 0.84 μg/ml) and increases survival of P. densiflora trees inoculated with B. xylophilus.

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