Oligomycin D

An inhibitor of mitochondrial F1FO-ATPase

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500ug

￥5650.00

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2.5mg

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货号: ajci73254
CAS: 1404-59-7
别名: 芦他霉素,26-Demethyloligomycin A
分子式: C44H72O11
分子量: 777
纯度: >98%
溶解度: Soluble in methanol, or in ethanol, or in DMSO, or in DMF
储存: Store at -20°C
库存: 现货

Background

Oligomycin D is a macrolide antibiotic produced by several species of Streptomyces that inhibits the mitochondrial F1FO-ATPase and is used to uncouple oxidative phosphorylation from electron transport. [1] Oligomycin D is reported to inhibit K-Ras plasma membrane localization in MDCK cells with an IC50 value of 3.49 nM and is cytotoxic to SW620 colon cancer cells with an IC50 value of 36 µM.[2]

Reference:
[1]. Inoue, S., Mizutani, A., Sugita, R., et al. Purification and characterization of a novel protein activator of Ca2+/calmodulin-dependent protein kinase I. Biochemical and Biophysical Research Communications 215(3), 861-867 (1995).
[2]. Salim, A.A., Tan, L., Huang, X.-C., et al. Oligomycins as inhibitors of K-Ras plasma membrane localisation. Organic & Biomolecular Chemistry 14(2), 711-715 (2016).