Oritavancin (phosphate)

A semisynthetic glycopeptide antibiotic

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库存: 现货

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数量
2mg

￥562.00

450.00

- +
5mg

￥1062.00

850.00

- +
10mg

￥1787.00

1430.00

- +
50mg

￥5325.00

4260.00

- +
100mg

￥8525.00

6820.00

- +

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货号: ajci73272
CAS: 192564-14-0
别名: 奥利万星二磷酸盐; LY333328 diphosphate
分子式: C86H97Cl3N10O26?2H3PO4
分子量: 1989.1
纯度: >98%
溶解度: 50 mg/mL in DMSO?(?Need ultrasonic); 50 mg/mL in Water(Need ultrasonic)
储存: Store at -20°C
库存: 现货

Background

Oritavancin is a semisynthetic glycopeptide antibiotic that inhibits the growth of Gram-positive bacteria. It inhibits transglycosylation and transpeptidation in the bacterial cell wall to disrupt membrane integrity. Oritavancin inhibits the growth of clinical isolates from skin and soft-tissue infections, including methicillin-resistant and -susceptible S. aureus (MRSA, MSSA), vancomycin-resistant and -susceptible E. faecium (VREF, VSRF), as well as other staphylococci, streptococci, and enterococci (MIC90s = ≤0.008-0.5 mg/L). Oritavancin inhibits growth of S. aureus in a neutropenic-mouse thigh model of infection (ED50 = 0.95 mg/kg for a single dose). It improves survival in a mouse inhalation model of B. anthracis Ames anthrax when administered prophylactically pre- and postexposure and when administered post symptom development. Formulations containing oritavancin have been used to treat bacterial skin infections.