PD 089828

An inhibitor of EGFR, PDGFβ, FGF, and c-Src

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库存: 现货

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数量
500ug

￥512.00

410.00

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1mg

￥975.00

780.00

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5mg

￥4025.00

3220.00

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货号: ajci73408
CAS: 179343-17-0
别名: EGF/FGF/PDGF Receptor Tyrosine Kinase Inhibitor
分子式: C18H18Cl2N6O
分子量: 405.3
纯度: >98%
溶解度: DMSO: 25 mg/ml,Ethanol: 1 mg/ml
储存: Store at -20°C
库存: 现货

Background

PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 µM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 = 0.18 µM). It is selective for these targets over insulin receptor tyrosine kinase, PKC, and CDK4 (IC50s = >50 µM) but does inhibit MAPK (IC50 = 7.1 µM). PD 089828 decreases PDGF-BB-, EGF-, and bFGF-induced phosphorylation of PDGFR, EGFR, and FGFR1, respectively, in a concentration-dependent manner in vitro. It also decreases serum-stimulated growth (IC50 = 1.8 µM after 8 days) and migration (IC50 = 4.5 µM) of rat aortic smooth muscle cells.