Phenylacetyl Coenzyme A (Phenylacetyl CoA)
Phenylacetyl CoA 是一种受体氧化还原酶。Phenylacetyl CoA 是一种膜结合的钼-铁-硫酶，参与反硝化菌 Thauera aromatica 中苯丙氨酸的厌氧代谢。
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包装价格促销价数量
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1mg￥3187.002000.00- +
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5mg￥12142.008500.00- +
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25mg￥18000.000.00- +
- 货号: ajci73494
- CAS: 7532-39-0
- 别名: Phenylacetyl Coenzyme A；Phenylacetyl CoA;苯乙酰辅酶A
- 分子式: C29H42N7O17P3S
- 分子量: 885.7
- 纯度: ＞98%
- 溶解度: Soluble in DMSO;PBS (pH 7.2): 10 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
Phenylacetyl coenzyme A (CoA) is a key intermediate in aerobic catabolism of phenylacetate in bacteria such as Pseudomonas, when cultured in minimal media using phenylacetate as the sole carbon source. 1It is a precursor in the synthesis of the antibiotic penicillin G((Item No. ajce45800) found in industrial strains of P. chrysogenum. Phenylacetyl-CoA also acts as an effector molecule of the TetR family transcriptional repressor PaaR in T. thermophilus and the GntR family transcriptional regulator PaaX in E. coli and Pseudomonas, binding to each protein to induce derepression of various genes.2
参考文献：
1.Miñambres, B., Martínex-Blanco, H., Olivera, E.R., et al. Molecular cloning and expression in different microbes of the DNA encoding Pseudomonas putida U phenylacetyl-CoA ligase. Use of this gene to improve the rate of benzylpenicillin biosynthesis in Penicillium chrysogenum. J. Biol. Chem. 271(52), 33531-33538 (1996).
2. Sakamoto, K., Agari, Y., Kuramitsu, S., et al. Phenylacetyl coenzyme A is an effector molecule of the TetR family transcriptional repressor PaaR from Thermus thermophilus HB8. J. Bacteriol. 193(17), 4388-4395 (2011).
