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- PI3-Kinase α Inhibitor 2
PI3-Kinase α Inhibitor 2
A PI3K p110α inhibitor
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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500ug￥437.00350.00- +
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1mg￥825.00660.00- +
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5mg￥3475.002780.00- +
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10mg￥6025.004820.00- +
- 货号: ajci73524
- CAS: 371943-05-4
- 别名: PI3Kα Inhibitor 2, Phosphatidylinositol 3Kinase α Inhibitor 2
- 分子式: C16H15N3O2S
- 分子量: 313.4
- 纯度: ＞98%
- 溶解度: DMF: 30 mg/ml,DMF:PBS(pH 7.2) (1:3): 0.25mg/ml,DMSO: 25 mg/ml,Ethanol: 1 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3Kα, β, and δ are class 1A enzymes composed of p110 and p85 subunits, whereas PI3Kγ is a class 1B PI3K composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit. PI3Kα inhibitor 2 is a selective inhibitor of PI3Kα with IC50 values of 2, 16, 660, and 220 nM for the α, β, γ, and 2Cβ isoforms, respectively. It inhibits PKA, KDR, PKCα, and cyclin E/Cdk2 significantly less effectively (IC50 = 91, 3.4, 466, and 28 µM, respectively). PI3Kα inhibitor 2 inhibits A375 melanoma cell proliferation with an IC50 value of 580 nM.
