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  • Prostratin
Prostratin的可视化放大

Prostratin

An HIV re-activator

原价
¥1150-13412
价格
920-10730
Prostratin的二维码

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  • 货号: ajci73700
  • CAS: 60857-08-1
  • 别名: 13-O-乙酰基-12-脱氧佛波醇,13-O-Acetylphorbol
  • 分子式: C22H30O6
  • 分子量: 390.5
  • 纯度: >98%
  • 溶解度: 10mg/mL in DMSO,10mg/mL in DMF, 10mg/mL in Ethanol
  • 储存: Store at -20°C
  • 库存: 现货

Background

Activation of latent reservoirs of HIV-infected cells is a treatment strategy designed to reduce viral load and eliminate the perpetuation of retroviral infection. Prostratin is a non-tumor promoting phorbol ester that potently induces HIV-1 reactivation in latent reservoirs of infected Jurkat-LAT-GFP cells with an IC50 value of ~0.5 µM. [1] Originally, prostratin was isolated from plant sources including P. prostrata, E. cornigera, and H. nutans. [2] The effects of prostratin are mediated through activation of NF-κB via protein kinase C and by downregulation of HIV-1 receptor CD4 expression and its co-receptors CXCR4 and CCR5.[3][4][5]


Reference:
[1]. Bedoya, L.M., Márquez, N., Martínez, N., et al. SJ23B, a jatrophane diterpene activates classical PKCs and displays strong activity against HIV in vivo. Biochemical Pharmacology 77, 965-978 (2009).
[2]. Wender, P.A., Kee, J.M., and Warrington, J.M. Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIV. Science 320, 649-652 (2008).
[3]. Williams, S.A., Chen, L.F., Kwon, H., et al. Prostratin antagonizes HIV latency by activating NF- k B. The Journal of Biological Chemisty 279(40), 42008-42017 (2004).
[4]. Biancotto, A., Grivel, J.C., Gondois-Rey, F., et al. Dual role of prostratin in inhibition of infection and reactivation of human immunodeficiency virus from latency in primary blood lymphocytes and lymphoid tissue. Journal of Virology 78(19), 10507-10515 (2004).
[5]. Hezareh, M., Moukil, M.A., Szanto, I., et al. Mechanisms of HIV receptor and co-receptor down-regulation by prostratin: Role of conventional and novel PKC isoforms. Antivir. Chem. Chemother. 15, 207-222 (2004).

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