PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt)

A synthetic analog of natural PtdIns

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库存: 现货

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数量
100ug

￥762.00

610.00

- +
500ug

￥3462.00

2770.00

- +
1mg

￥6075.00

4860.00

- +
5mg

￥26337.00

21070.00

- +

已选 0 种 0 瓶

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货号: ajci73742
CAS: 1628353-02-5
别名: DPPI3,4,5P3, Phosphatidylinositol3,4,5triphosphate C16
分子式: C41H78O22P4?4Na
分子量: 1138.9
纯度: >98%
溶解度: CHCl3:CH3OH:Water (2.5:3:1): 3.8 mg/ml,PBS (pH 7.2): 10 mg/ml
储存: Store at -20°C
库存: 现货

Background

The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals. PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and the Akt-family of GTPase activating proteins are examples of PtdIns-(3,4,5)-P3-binding proteins. Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. For further reading on inositol phospholipids, see also references and .