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- Acyltransferase
- RU-SKI 43 (hydrochloride)
RU-SKI 43 (hydrochloride)
An inhibitor of hedgehog acyltransferase
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包装价格促销价数量
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1mg￥387.00310.00- +
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5mg￥1225.00980.00- +
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10mg￥1787.001430.00- +
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- 货号: ajci73952
- CAS: 1782573-67-4
- 别名: RU-SKI 43（盐酸盐）
- 分子式: C22H30N2O2S?HCl
- 分子量: 423
- 纯度: ＞98%
- 溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
Hedgehog acyltransferase (Hhat) is an N-palmitoyltransferase that acylates Sonic hedgehog (Shh), which is critical for signaling through Shh. RU-SKI 43 is an inhibitor of Hhat (IC50 = 0.85 µM). It blocks palmitoylation of Shh without affecting palmitoylation of H-Ras or Fyn, myristoylation of c-Src, or acylation of Wnt3a. RU-SKI 43 is cell-permeable and inhibits both autocrine and paracrine Shh-induced activation of Gli-mediated transcription. In pancreatic cancer cells, RU-SKI 43 reduces both Gli1 activation and proliferation.
