Simeprevir (sodium salt)

A potent NS3/4A protease inhibitor

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库存: 现货

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促销价

数量
1mg

￥712.00

570.00

- +
5mg

￥2537.00

2030.00

- +
10mg

￥4675.00

3740.00

- +
25mg

￥10787.00

8630.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajci74024
CAS: 1241946-89-3
别名: 西咪匹韦钠; TMC435 sodium; TMC435350 sodium
分子式: C38H47N5O7S2?XNa
分子量: 749.9
纯度: >98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml,Ethanol: slightly soluble
储存: Store at -20°C
库存: 现货

Background

Simeprevir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease (Ki = 0.36 nM), a serine protease essential for HCV replication. It inhibits HCV viral replication with an EC50 value of 7.8 nM in Huh7 replicon cells using a luciferase-based assay. Simeprevir is effective against the HCV genotypes 1a and 1b in biochemical assays. In Huh7 replicon cells, it is synergistically effective when used in combination with IFN-α or NM-107 and has an additive effect when used with ribavirin . Formulations containing simeprevir have been used, alone or in combination with pegylated IFN-α and ribavirin, for the treatment of HCV.