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安捷凯生物医药，安捷凯化学
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  3. SMI-481
  • SMI-481
SMI-481的可视化放大

SMI-481

An inhibitor of Sec14

原价
￥300-775
价格
￥ 240-620
SMI-481的二维码

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  • 库存: 现货
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  • 货号: ajci74052
  • CAS: 432020-20-7
  • 别名:
  • 分子式: C17H15ClFN3O3
  • 分子量: 363.8
  • 纯度: >98%
  • 溶解度: DMF: 50 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml,DMSO: 30 mg/ml,Ethanol: 0.3 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

Phosphatidylinositol (PtdIns) transfer proteins (PITPs) mediate the exchange of PtdIns and phosphatidylcholine between membranes, a step required for a wide array of cellular processes including cell division. SMI-481 is an inhibitor of the yeast PITP Sec14, blocking both Sec14-mediated transfer of [3H]-PtdIns in vitro and growth (IC50s = 0.21 and 2.87 µM, respectively). Suppression of Sec14 expression leads to proportional reduction in SMI-481 inhibition, suggesting that SMI-481 acts specifically through Sec14. Moreover, SMI-481 does not affect [3H]-PtdIns transfer mediated by other yeast PITPs.

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