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  • TNF-α Antagonist
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TNF-α Antagonist

A peptidomimetic of the TNF-α receptor ligand binding site

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¥2037-16100
价格
1630-12880
TNF-α Antagonist的二维码

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  • 货号: ajci74366
  • CAS: 199999-60-5
  • 别名: WP9QY
  • 分子式: C58H71N11O15S2
  • 分子量: 1226.4
  • 纯度: >98%
  • 溶解度: DMSO: 5 mg/ml,DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml
  • 储存: Store at -20°C
  • 库存: 现货

Background

TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor. By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-κB (RANK) and TNF-α's recruitment and activation of osteoclasts. TNF-α antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destruction.

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