Tubastatin A (trifluoroacetate salt)

A potent HDAC6 inhibitor

原价

￥575-2600

价格

￥ 460-2080

Tubastatin A (trifluoroacetate salt)的二维码

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库存: 现货

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产品引用

货号: ajci74432
CAS: 1239262-52-2
别名: N-羟基-4-((2-甲基-3,4-二氢-1H-吡啶并[4,3-B]吲哚-5(2H)-基)甲基)苯甲酰胺2,2,2-三氟乙酸盐
分子式: C20H21N3O2?CF3COOH
分子量: 449.4
纯度: >98%
溶解度: DMF: 5 mg/ml,DMSO: 5 mg/ml,DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml,Ethanol: 0.2 mg/ml
储存: Store at -20°C
库存: 现货

Background

Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s >16 μM), excluding HDAC8 (IC50 = 0.9 μM). Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.

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Tubastatin A (trifluoroacetate salt)

Tubastatin A (trifluoroacetate salt)详情

Background