Umirolimus
A rapamycin derivative
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包装价格促销价数量
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5mg￥3600.002880.00- +
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10mg￥5700.004560.00- +
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25mg￥11275.009020.00- +
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50mg￥17037.0013630.00- +
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100mg￥26437.0021150.00- +
- 货号: ajci74470
- CAS: 851536-75-9
- 别名:
- 分子式: C55H87NO14
- 分子量: 986.3
- 纯度: ＞98%
- 溶解度: DMF: Soluble,DMSO: Soluble,Ethanol: Soluble,Methanol: Soluble
- 储存: Store at -20°C
- 库存: 现货
Background
Umirolimus is a semi-synthetic macrocyclic lactone and a derivative of rapamycin that has immunosuppressive and anti-inflammatory effects. It halts the cell cycle at the G1 phase through an IL-2/mTOR-mediated pathway and inhibits proliferation of human smooth muscle cells. In a porcine overstretch model, coronary stents containing umirolimus for localized delivery to the vessel wall reduced stenosis by 50% and led to less thickening of the vessel wall than a bare metal stent. Rapamycin, and likely its derivatives, binds to the cytosolic FK-binding protein 12 (FKBP12) to inhibit the mammalian target of rapamycin (mTOR) pathway. Formulations containing umirolimus have been used in coronary stents for localized delivery to the vessel wall.
