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- (±)10(11)-EDP Ethanolamide
(±)10(11)-EDP Ethanolamide
An ω-3 endocannabinoid epoxide and CB receptor agonist
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包装价格促销价数量
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25ug￥1487.001190.00- +
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50ug￥2825.002260.00- +
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100ug￥5312.004250.00- +
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- 货号: ajci74782
- CAS: 2123484-71-7
- 别名: 10,11-EDP-EA, 10,11-EDP epoxide, 10,11-epoxy Docosapentaenoic Ethanolamide
- 分子式: C24H37NO3
- 分子量: 387.6
- 纯度: ＞98%
- 溶解度: DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
- 储存: Store at -20°C
- 库存: 现货
Background
(±)10(11)-EDP ethanolamide is an ω-3 endocannabinoid epoxide and cannabinoid (CB) receptor agonist (EC50s = 0.43 and 22.5 nM for CB1 and CB2 receptors, respectively). It is produced though direct epoxygenation of docosahexaenoyl ethanolamide by cytochrome P450 (CYP) epoxygenases. 10,11-EDP epoxide (12.5 and 25 μM) reduces the viability of 143B metastatic osteosarcoma cells. It induces apoptosis and inhibits cell migration in a wound-healing assay in 143B, MG63, and HOS osteosarcoma cells. (±)10(11)-EDP ethanolamide also reduces tube formation by human umbilical vein endothelial cells (HUVECs) in a Matrigel? assay.
