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  • Solutol HS-15
Solutol HS-15的可视化放大

Solutol HS-15

原价
¥250.00-875.00
价格
200.00-650.00
Solutol HS-15的二维码

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SolutolHS-15是一种通透性增强剂。

货号:ajce44266
CAS:61909-81-7
分子式:(C2H4O)nC18H36O3
分子量:
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Solutol HS-15 is a permeability enhancer.


Solutol HS-15 is a permeability enhancer. A general decline in cell metabolic activity is seen for all three tested cell lines as the concentration of Solutol HS-15 solution is increased. Results demonstrate that Solutol HS-15 promotes the apical-to-basolateral translocation of a model protein (insulin) across Calu-3 monolayers when applied at 37°C. Furthermore there is no statistically significant increase in insulin permeability in the presence of Solutol HS-15, relative to the respective control, at 4°C. Solutol HS-15 treated cells show a statistically significant increase in permeability towards lower molecular weight permeants (5 to 22 kDa) and an absence of a statistically significant increase in permeability of proteins with larger molecular weight, namely albumin and IgG (P>0.05 relative to control)[1].


参考文献
[1]. Shubber S, et al. Mechanism of mucosal permeability enhancement of CriticalSorb? (Solutol? HS15) investigated in vitro in cell cultures. Pharm Res. 2015 Feb;32(2):516-27.


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