Taprenepag (CP-544326)
A potent EP2 receptor agonist
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包装价格促销价数量
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5mg￥1412.001130.00- +
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10mg￥2062.001650.00- +
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50mg￥6175.004940.00- +
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100mg￥10287.008230.00- +
- 货号: ajce44378
- CAS: 752187-80-7
- 别名: CP-544326
- 分子式: C24H22N4O5S
- 分子量: 478.52
- 纯度: ＞98%
- 溶解度: DMSO : ≥ 31 mg/mL (64.78 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
CP 544,326 is a potent agonist of E prostanoid (EP) receptor 2 (IC50s = 10 and 15 nM for human and rat EP2, respectively).1 It is selective for EP2 over other EP receptors (IC50s = >3,200 nM for EP1, EP3, and EP4) and a panel of 37 G protein-coupled receptors (≤30% inhibition at a concentration of 10 μM). CP 544,326 increases cAMP levels in HEK293 cells expressing human EP2 (EC50 = 2.8 nM). CP 544,326 has poor corneal permeability in an ex vivo rabbit corneal model. However, PF-04217329, a cell-permeable prodrug form of CP 544,326, reduces intraocular pressure in rabbit, canine, and marmoset models of glaucoma.
1.Prasanna, G., Carreiro, S., Anderson, S., et al.Effect of PF-04217329 a prodrug of a selective prostaglandin EP2 agonist on intraocular pressure in preclinical models of glaucomaExp. Eye Res.93(3)256-264(2011)
