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E3 ligase Ligand-Linker Conjugates 4 是一种合成的 E3 ligase Ligand-Linker Conjugates 结合物,它包含基于 (S,R,S)-AHPC 的 VHL 配体和 PROTAC 技术中使用的 4 单元 PEG 接头。
E3 ligase Ligand-Linker Conjugates 4 is a synthesized compound that incorporates an E3 ligase ligand and a linker used in PROTAC technology.
E3 ligase Ligand-Linker Conjugates 4 together with JQ1 triggers the intracellular destruction of BET proteins[1].
[1]. Zengerle M, et al. Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS Chemical Biology (2015), 10(8), 1770-1777.
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