A natural isoflavone
Neobavaisoflavone is a natural isoflavone that was first isolated from seeds of P. corylifolia, which are used in traditional herbal medicine to treat various skin diseases. Neobavaisoflavone has been found to have diverse effects in isolated mammalian cells, including inhibiting DNA polymerase and carboxylesterase 1 (Ki = 5.3 ?M).1,2 It also displays antibiotic activity against Gram-negative multidrug resistant bacteria.3
1.Sun, N.J., Woo, S.H., Cassady, J.M., et al.DNA polymerase and topoisomerase II inhibitors from Psoralea corylifoliaJ. Nat. Prod.61(3)362-366(1998) 2.Sun, D.X., Ge, G.B., Dong, P.P., et al.Inhibition behavior of fructus psoraleae's ingredients towards human carboxylesterase 1 (hCES1)Xenobiotica46(6)503-510(2016) 3.Mbaveng, A.T., Sandjo, L.P., Tankeo, S.B., et al.Antibacterial activity of nineteen selected natural products against multi-drug resistant Gram-negative phenotypesSpringerPlus4:823(2015)
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