A precursor in the synthesis of PROTACs
TC-E3 5032 is a precursor in the synthesis of homodimeric proteolysis-targeting chimera technologies (PROTACs).1 It has been used to attach various linkers at position 4 to produce alkylated pomalidomide derivatives as intermediates in the synthesis of homodimeric PROTACs. It has also been used as an intermediate in the synthesis of HDAC6 and anaplastic lymphoma kinase (ALK) degraders.2,3
1.Steinebach, C., Lindner, S., Udeshi, N.D., et al.Homo-PROTACs for the chemical knockdown of cereblonACS Chem. Biol.13(9)2771-2782(2018) 2.Yang, K., Song, Y., Xie, H., et al.Development of the first small molecule histone deacetylase 6 (HDAC6) degradersBioorg. Med. Chem. Lett.28(14)2493-2497(2018) 3.Powell, C.E., Gao, Y., Tan, L., et al.Chemically induced degradation of anaplastic lymphoma kinase (ALK)J. Med. Chem.61(9)4249-4255(2018)
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