CP-66948

CP-66948是histamineH2受体拮抗剂，能够抑制胃酸分泌，保护粘膜的作用。

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
1mg

￥6200.00

4960.00

- +
5mg

￥12175.00

9740.00

- +
10mg

￥20762.00

16610.00

- +
20mg

￥36562.00

29250.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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Background

CP-66948 is a histamine H2-receptor antagonist with gastric antisecretory activity and mucosal protective properties.

The affinity of CP-66,948 for the guinea pig atria histamine H2-receptor is 15 times greater than that of cimetidine and seven times greater than that of ranitidine. In vivo, the ED50 value for inhibition of gastric acid secretion in pylorus-ligated rats is 2 mg/kg intraduodenally, and in histamine or pentagastrin-stimulated Heidenhain pouch dogs the antisecretory ED50 values are 0.3 mg/kg per os and 1.0 mg/kg per os, respectively. CP-66,948 also inhibits ethanol-induced gastric hemorrhagic lesions in rats following either oral or systemic administration (ED50 values of 12 mg/kg per os and 6 mg/kg subcutaneously)[1].

[1]. Hakkinen JP, et al. CP-66,948: an antisecretory histamine H2-receptor antagonist with mucosal protective properties. Dig Dis Sci. 1991 Dec;36(12):1721-8.