(-)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.
(-)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.
(-)-Norepinephrine inhibits the production of TNF-α, IL-6, and CXCL2/MIP-2 and promotes the secretion of IL-10 from LPS-stimulated murine alveolar macrophages. (-)-Norepinephrine down-regulates NF-κB activation in stimulated alveolar macrophages. [2]
Injection of (-)-Norepinephrine into senescence-accelerated prone 8 (SAMP8) mice reverses formaldehyde accumulation and (-)-Norepinephrine deficiency and restored the magnitude of long-term potentiation and memory. [3]
(-)-去甲肾上腺素（Arterenol、Levarterenol、L-Noradrenaline）是一种天然神经递质和激素。它是肾上腺素能受体的激动剂，对α1、α2和β1肾上腺素能受体的Ki值分别为330、56和740 nM。
(-)-去甲肾上腺素抑制LPS刺激小鼠肺泡巨噬细胞产生TNF-α、IL-6和CXCL2/MIP-2，并促进IL-10的分泌。(-)-去甲肾上腺素能够下调受刺激的肺泡巨噬细胞中NF-κB的活化。[2]
将(-)-去甲肾上腺素注射到老化加速易感8号（SAMP8）小鼠体内可以逆转甲醛积累和(-)-去甲肾上腺素缺乏，并恢复长时程增强和记忆的程度。[3]
[1] Ramos BP, et al. Pharmacol Ther. 2007, 113(3):523-36. [2] Cong Z, et al. Clin Sci (Lond). 2020 Jul 31;134(14):1957-1971. [3] Mei Y,et al. Aging Cell. 2015 Aug;14(4):659-68.
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Cell experiment: |
Subcutaneous preadipocytes derived from a 38-year old non-diabetic female donor are immortalized with TERT and HPV E6/E7. For the current studies, a stable diploid clone (referred to as clone B) with consistent differentiation capacity is isolated by ring cloning. Cells are grown in preadipocyte PGM2 media. Once cells are confluent, differentiation is induced by incubation in differentiation media consisting of dexamethasone, IBMX, indomethacin, and additional insulin. Cells are differentiated for 10 days. Prior to treatment, media is replaced with PGM2 media for one day and then switched to serum-free media overnight for treatments. Adipocytes are treated for 6 hours with vehicle, Norepinephrine (NE, 10 μM), CGP (10 nM), or Norepinephrine (NE) and CGP[2]. |
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参考文献: [1]. MacGregor DA, et al. Relative efficacy and potency of beta-adrenoceptor agonists for generating cAMP in human lymphocytes. Chest. 1996 Jan;109(1):194-200. |
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