Cyclo(his-pro) (Cyclo(histidyl-proline))

A cyclic neuropeptide and metabolite of TRH

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库存: 现货

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25mg

￥950.00

760.00

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50mg

￥1662.00

1330.00

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100mg

￥2587.00

2070.00

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货号: ajce45854
CAS: 53109-32-3
别名: 环(组氨酰-脯氨酰),Cyclo(histidyl-proline); Histidylproline diketopiperazine
分子式: C11H14N4O2
分子量: 234.25
纯度: >98%
溶解度: Water : ≥ 30 mg/mL (128.07 mM)
储存: Store at -20°C
库存: 现货

Background

Cyclo(L-His-L-Pro) is an endogenous cyclic neuropeptide and a metabolite of thyrotropin-releasing hormone (TRH).¹ It is formed in the hypothalamus via the hydrolytic removal of pyroglutamic acid from TRH followed by non-enzymatic cyclization but is also synthesized de novo.² It is ubiquitously expressed in the CNS, but is also found in the gastrointestinal tract and blood. Cyclo(L-His-L-Pro) (50 ?M) reduces LPS-induced production of reactive oxygen species (ROS) and nitric oxide (NO), as well translocation of NF-κB in BV-2 microglia. Levels of cyclo(L-His-L-Pro) are increased in rat brain after six weeks of continuous ethanol consumption and cyclo(L-His-L-Pro) reduces ethanol-induced sleep time in rats when administered at a dose of 1 ?mol/kg.^1,3 Cyclo(L-His-L-Pro) induces analgesia in the hot-plate test and reduces acetic acid-induced writhing in mice, effects that can be partially reversed by the opioid antagonist naloxone.¹

1.Prasad, C.Neurobiology of cyclo(His-Pro)Ann. N. Y. Acad. Sci.553(1)232-251(1989) 2.Grottelli, S., Ferrari, I., Pietrini, G., et al.The role of cyclo(His-Pro) in neurodegenerationInt. J. Mol. Sci.17(8)1332(2016) 3.Prasad, C., Matsui, T., and Peterkofsky, A.Antagonism of ethanol narcosis by histidyl-proline diketopiperazineNature268(5616)142-144(1977)